Prescription only
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Biest Cream
Estriol and estradiol. Prescribed after a provider review.
Hormone Health
The same compounded bioidentical estrogen as a topical.
- Form
- Topical cream, daily
- Labs
- Required; $89.50 HRT panel, paid to the lab
- Prescribed for
- Female
- Licensed providers
- Pharmacy named on every label
- 12-month price lock
Quick answer
Biest Cream at a glance
Biest cream delivers the same estrogen blend as the capsule, but through your skin instead of your digestive system.
How it’s taken: topical cream, daily.
Bloodwork is required before and during treatment.
A prescription from a licensed provider is required.
Updated
How Biest Cream works
Biest cream delivers the same estrogen blend as the capsule, but through your skin instead of your digestive system.
Topical delivery bypasses the liver, which means the estrogen goes directly into your bloodstream without being processed first.
Many providers prefer this route for estrogen because it avoids the liver's first-pass effect and produces more stable blood levels.
What Biest is
A compounded bioidentical preparation. FDA has raised concerns specifically about marketing compounded hormone preparations as safer or more natural than approved products. We do not make that claim, and you should be sceptical of anyone who does.
Two estrogens, in a set ratio
Estriol and estradiol combined, in a cream applied to the skin.
Estriol has no approved product
Estriol is not a component of any FDA-approved drug in the United States.
Transfer is a real risk
Topical hormone preparations can transfer to another person by skin contact. Your provider will tell you how to apply it.
Not FDA-approved
Compounded Biest is not an FDA-approved drug product and FDA does not review it for safety, effectiveness or quality.
Biest Cream questions
Where do I apply it?
Typically to thin-skinned areas like your inner wrist or inner arm. Your provider will give you specific instructions.
See if Biest Cream is right for you.
Answer a few questions and a licensed provider will review your options.
Start your assessmentImportant safety information
Last updated
Testosterone is a Schedule III controlled substance.
Prescribing it is subject to DEA telemedicine rules and state controlled-substance requirements in addition to ordinary standards of care.
Compounded hormone preparations, including compounded testosterone, Biest, progesterone and thyroid preparations, are not FDA-approved drug products.
Estriol is not a component of any FDA-approved drug.
Testosterone therapy requires baseline and ongoing laboratory monitoring.
Your provider determines what testing is required and when.
Reported risks include erythrocytosis, effects on fertility and spermatogenesis, worsening of sleep apnoea, acne, and cardiovascular considerations your provider will review against your history.
Not appropriate in pregnancy, in anyone who is or may become pregnant, or where a provider identifies a contraindication such as active prostate or breast malignancy.
FDA has raised concerns specifically about marketing compounded hormone preparations as safer or more natural than approved products.
We do not make that claim and you should be sceptical of anyone who does.
Compounded medication, prepared by a state-licensed pharmacy for individual patients. Compounded drugs are not FDA-approved, and the FDA does not review them for safety, effectiveness or quality. Prescribed only if your provider determines it is clinically appropriate for you.
This is not a complete list of risks. Talk with your provider and read the full prescribing information or medication guide.