Off-label use
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Anastrozole
Anastrozole. Prescribed after a provider review.
Hormone Health
Compounded anastrozole, used to manage estrogen for some men on testosterone. Not everyone needs it.
- Form
- Oral tablet
- Labs
- Required; $88.25 TRT panel, paid to the lab
- Prescribed for
- Male
- Licensed providers
- Pharmacy named on every label
- 12-month price lock
Quick answer
Anastrozole at a glance
When you're on testosterone replacement therapy, some of that testosterone naturally converts to estrogen.
How it’s taken: oral tablet.
Bloodwork is required before and during treatment.
A prescription from a licensed provider is required.
Updated
How Anastrozole works
When you're on testosterone replacement therapy, some of that testosterone naturally converts to estrogen.
For most men, this is fine — but some men convert too much, leading to side effects like water retention, mood swings, sensitive nipples, or breast tissue growth (gynecomastia).
Anastrozole blocks that conversion, keeping your estrogen in the right range.
Your provider will check your estrogen levels with bloodwork and only prescribe this if you actually need it.
What anastrozole is
Anastrozole is an FDA-approved aromatase inhibitor. Its approved indication is breast cancer; use alongside hormone therapy is off-label.
An aromatase inhibitor
It reduces the conversion of androgens to estrogens by blocking the aromatase enzyme.
FDA-approved, for something else
Anastrozole is approved for hormone-receptor-positive breast cancer. Use in a testosterone-therapy context is off-label.
Prescribed from labs, not symptoms
Whether it is appropriate depends on bloodwork your provider orders and reads.
Not routine
It is not part of every hormone protocol, and over-suppressing estrogen carries its own problems. Your provider decides.
Anastrozole questions
Do I need this if I'm on TRT?
Not necessarily — only if your estrogen is actually elevated. Your provider will check your bloodwork and only prescribe it if needed.
What happens if I take too much?
Crashing your estrogen too low feels terrible — joint pain, low mood, no libido. That's why we monitor with bloodwork rather than just guessing.
See if Anastrozole is right for you.
Answer a few questions and a licensed provider will review your options.
Start your assessmentImportant safety information
Last updated
Testosterone is a Schedule III controlled substance.
Prescribing it is subject to DEA telemedicine rules and state controlled-substance requirements in addition to ordinary standards of care.
Compounded hormone preparations, including compounded testosterone, Biest, progesterone and thyroid preparations, are not FDA-approved drug products.
Estriol is not a component of any FDA-approved drug.
Testosterone therapy requires baseline and ongoing laboratory monitoring.
Your provider determines what testing is required and when.
Reported risks include erythrocytosis, effects on fertility and spermatogenesis, worsening of sleep apnoea, acne, and cardiovascular considerations your provider will review against your history.
Not appropriate in pregnancy, in anyone who is or may become pregnant, or where a provider identifies a contraindication such as active prostate or breast malignancy.
FDA has raised concerns specifically about marketing compounded hormone preparations as safer or more natural than approved products.
We do not make that claim and you should be sceptical of anyone who does.
Compounded medication, prepared by a state-licensed pharmacy for individual patients. Compounded drugs are not FDA-approved, and the FDA does not review them for safety, effectiveness or quality. Prescribed only if your provider determines it is clinically appropriate for you.
This is not a complete list of risks. Talk with your provider and read the full prescribing information or medication guide.