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Weight Loss Program
GLP-1 + Tesamorelin
A compounded GLP-1 medication that acts on appetite signals, with compounded tesamorelin, a daily growth hormone–releasing peptide injection your provider may add to your plan. Choose semaglutide or tirzepatide, by injection or as a dissolving tablet, on a 3-month plan.
- Includes
- GLP-1 + tesamorelin
- GLP-1 choice
- Semaglutide or tirzepatide
- Form
- GLP-1 shot or tablet + daily tesamorelin injection
- Plan
- 3 months at a time
- Made by
- State-licensed compounding pharmacy
What's in the program
Choose your GLP-1, with tesamorelin alongside it.
Semaglutide
Acts on GLP-1 to quiet cravings. Weekly injection or daily dissolving tablet.
About Semaglutide
Tirzepatide
Acts on GLP-1 and GIP. Weekly injection or daily dissolving tablet.
About Tirzepatide
Tesamorelin
A growth hormone–releasing peptide, injected under the skin once a day. Use for weight loss is off-label.
About TesamorelinProgram vs. separately
Same medications, same provider care, on one 3-month plan.
| Program (quarterly, per month) | Separately (quarterly, per month) | |
|---|---|---|
| Semaglutide injection + tesamorelin | $249 | $288 |
| Semaglutide tablet (ODT) + tesamorelin | $229 | $268 |
| Tirzepatide injection + tesamorelin | $339 | $378 |
| Tirzepatide tablet (ODT) + tesamorelin | $259 | $298 |
Why they are prescribed together
GLP-1 medications act on appetite signals, which can help you feel full sooner. Individual results vary.
Tesamorelin mimics GHRH, the hormone that signals your pituitary gland to release more of your own growth hormone, which plays a role in how your body stores and uses fat. A brand-name version is FDA-approved only to reduce excess belly fat in adults with HIV-associated lipodystrophy; prescribing it for weight loss is off-label. Because it can raise IGF-1 and affect blood sugar, your provider may check labs before and during treatment.
What to expect
Everyone responds differently. Your provider checks in and adjusts your plan along the way.
Weeks 1–4
Your GLP-1 starts at a low dose. If your provider adds tesamorelin, it is a daily injection; redness or itching where you inject is common.
Months 2–3
GLP-1 doses increase as tolerated. Your provider may check IGF-1 and blood sugar and adjust your plan.
Months 4+
Doses are adjusted based on your progress, side effects, and labs. Tesamorelin's effects generally fade after stopping, so your provider reviews whether to continue.
Is it right for you?
Your provider reviews each medication separately before prescribing.
Often a good fit
- Adults with a BMI of 30 or higher, or 27 or higher with a weight-related condition
- Comfortable with a daily injection
- Willing to do labs if your provider asks
Usually not a fit
- Personal or family history of medullary thyroid cancer or MEN 2
- Pregnant, planning pregnancy, or breastfeeding
- History of pancreatitis
- Pituitary problems, pituitary surgery, or radiation to the head
- Active cancer
- Allergy to tesamorelin or mannitol
Not a complete list. Tell your provider about all health conditions and medications.
Possible side effects
Most side effects are mild. Your care team is a message away if something doesn't feel right.
Semaglutide or tirzepatide
Tesamorelin
Get medical help right away for
- Severe stomach pain that won't go away, with or without vomiting
- A lump or swelling in your neck, trouble swallowing, or hoarseness
- Pain in your upper right belly, fever, or yellowing skin or eyes
- Increased thirst or frequent urination (possible high blood sugar)
- Signs of an allergic reaction, like hives, swelling of your face or throat, or trouble breathing
For a medical emergency, call 911.
How to take it
Always follow the directions on your labels and from your provider.
GLP-1 on schedule
Take your GLP-1 as directed: a weekly injection or a daily dissolving tablet.
Tesamorelin daily
Inject under the skin of your belly once a day, at about the same time, changing the spot each day.
Store it properly
Follow the storage and mixing directions on each label. Injectables usually need refrigeration.
Program questions
Can I order the program today?
Not as a bundle yet. Program pricing hasn't been published. You can start with semaglutide or tirzepatide on its own now, and tesamorelin is available as its own treatment if your provider prescribes it.
Is tesamorelin FDA-approved for weight loss?
No. A brand-name version is FDA-approved only to reduce excess belly fat in adults with HIV-associated lipodystrophy. Prescribing it for weight loss is off-label, and the version we prescribe is compounded and not FDA-approved.
Semaglutide or tirzepatide?
Semaglutide acts on one appetite hormone and tirzepatide acts on two. Your provider helps you choose based on your history and goals.
Is there a monthly plan?
No. The pharmacy fills this program three months at a time, so it is offered on a 3-month plan only.
Start with a single treatment
Start with your GLP-1.
Answer a few questions and a licensed provider will review your options.
See semaglutideImportant safety information
Last updated
Semaglutide or tirzepatide: GLP-1 medications may cause thyroid C-cell tumors, including medullary thyroid carcinoma, based on studies in rodents; it is unknown whether this happens in people. Do not use if you or a family member has had medullary thyroid carcinoma or if you have MEN 2. Other serious risks include pancreatitis, gallbladder problems, low blood sugar when used with other diabetes medicines, kidney problems from dehydration, serious allergic reactions, increased heart rate, and changes in vision for people with diabetic retinopathy. Watch for changes in mood or thoughts of self-harm and tell your provider right away.
Tesamorelin: Tesamorelin can cause injection site reactions, joint pain, fluid retention, and increased blood sugar, and can raise IGF-1 levels. Do not use it if you have pituitary problems, have had pituitary surgery or radiation to the head, have active cancer, are pregnant, or are allergic to tesamorelin or mannitol. Use for weight loss is off-label. Egrifta® is a registered trademark of its owner.
Some medications in this program are prescribed off-label, meaning for a use not listed on their FDA-approved label. Your provider will discuss the benefits and risks with you.
Compounded medication, prepared by a state-licensed pharmacy for individual patients. Compounded drugs are not FDA-approved, and the FDA does not review them for safety, effectiveness or quality. Prescribed only if your provider determines it is clinically appropriate for you.
This is not a complete list of risks. Talk with your provider and read the full prescribing information or medication guide for each medication.