Off-label use
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Low-Dose Naltrexone
Naltrexone hydrochloride. Prescribed after a provider review.
Weight Loss
Compounded low-dose capsule, taken daily. Your provider decides whether it fits your plan. Individual results vary.
- Form
- Oral capsule, daily
- Licensed providers
- Pharmacy named on every label
- 12-month price lock
Quick answer
Low-Dose Naltrexone at a glance
Low-dose naltrexone (LDN) is prescribed off-label and supervised by a licensed provider.
How it’s taken: oral capsule, daily.
A prescription from a licensed provider is required.
Updated
How Low-Dose Naltrexone works
Low-dose naltrexone (LDN) is prescribed off-label and supervised by a licensed provider.
It is used at doses much lower than those prescribed for addiction treatment.
Your provider will review your full health history and medication list to determine whether LDN is appropriate for you.
Dispensed by a state board-licensed compounding pharmacy.
What low-dose naltrexone is
Naltrexone is an FDA-approved opioid antagonist. Low-dose use is a fraction of the approved dose and is off-label.
An approved medication, at a different dose
Naltrexone is FDA-approved at 50 mg for alcohol and opioid dependence. Low-dose use means a small fraction of that.
Low-dose use is off-label
FDA has not evaluated naltrexone at these doses for any of the uses it is compounded for.
An opioid antagonist
It blocks opioid receptors. Tell your provider about every medication you take, including anything for pain.
Compounded to strength
The low strengths are not commercially available, which is why the preparation is compounded.
Low-Dose Naltrexone questions
Is this the same naltrexone used for addiction?
Same medication, very different dose. Addiction treatment uses 50mg. LDN uses 1.5–4.5mg — about 10x less. The effects at this dose are completely different.
Will it affect my other medications?
It can interact with opioid-based medications. Your provider will review your full medication list before prescribing.
See if Low-Dose Naltrexone is right for you.
Answer a few questions and a licensed provider will review your options.
Start your assessmentImportant safety information
Last updated
These are compounded or off-label prescriptions used alongside a weight-management protocol where a provider determines they are appropriate.
Low-dose naltrexone is a strength that is not commercially manufactured — the approved product is 50mg — which is a legitimate reason to compound and is documented as such.
Naltrexone must not be taken with opioid medication and will precipitate withdrawal in anyone who is opioid-dependent.
Tell your provider about every medication you take.
Ondansetron can affect cardiac conduction.
Your provider reviews your history and other medications before prescribing it.
Lipotropic injections are not FDA-approved for weight loss and we make no weight-loss efficacy claim for them.
Compounded medication, prepared by a state-licensed pharmacy for individual patients. Compounded drugs are not FDA-approved, and the FDA does not review them for safety, effectiveness or quality. Prescribed only if your provider determines it is clinically appropriate for you.
This is not a complete list of risks. Talk with your provider and read the full prescribing information or medication guide.