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ED Combo ODT
Three ingredients, one tablet. Dissolves in your mouth.
- Sildenafil + tadalafil
- Plus PT-141
- Once a day, max
Compounded sildenafil + tadalafil + PT-141 dissolving tablet
A compounded tablet that dissolves in your mouth. It combines sildenafil and tadalafil, which improve blood flow, with PT-141, which acts on arousal, plus L-citrulline.
- Form
- Dissolving tablet (ODT)
- When to take
- Before sex, as your label directs
- Contains
- Sildenafil 55 mg · tadalafil 7 mg · PT-141 1 mg · L-citrulline
- Made by
- State-licensed compounding pharmacy
Choose your plan
No charge unless a provider approves · Start assessment
12-month price lock · Licensed providers · Pharmacy named on every label
Quick answer
ED Combo ODT at a glance
A compounded tablet that dissolves in your mouth.
How it’s taken: dissolving tablet (ODT), before sex, as your label directs.
It starts at $49/mo at Surna, with provider care included.
A prescription from a licensed provider is required. It’s compounded by a state-licensed pharmacy and is not FDA-approved.
Updated
How ED Combo ODT works
Sildenafil and tadalafil block PDE5, an enzyme that limits blood flow, so your body’s natural response to arousal works more easily.
PT-141 (bremelanotide) works differently, on brain pathways involved in desire and arousal. L-citrulline is an amino acid your body uses to make nitric oxide.
What to expect
Everyone responds differently. Your provider checks in and adjusts your plan along the way.
First use
Let the tablet dissolve before sex, following the timing on your label.
First few uses
Your provider may adjust your plan based on results and side effects.
Ongoing
Refills ship automatically in plain packaging.
Is it right for you?
Your provider makes the final call after reviewing your health history.
Often a good fit
- Trouble getting or keeping an erection
- Want one tablet instead of separate medications
- Single ED medications weren’t enough
Usually not a fit
- Take nitrates for chest pain, like nitroglycerin, or the medication riociguat
- Told by a doctor that sexual activity isn't safe for your heart
- Recent heart attack or stroke
- Use recreational 'poppers' (amyl nitrite)
- Uncontrolled high blood pressure or heart disease
Not a complete list. Tell your provider about all health conditions and medications.
Possible side effects
Most side effects are mild. Your care team is a message away if something doesn't feel right.
More common
Get medical help right away for
- An erection that lasts more than 4 hours
- Sudden loss of vision in one or both eyes
- Sudden decrease or loss of hearing
- Chest pain, dizziness, or nausea during sex
For a medical emergency, call 911.
How to take it
Always follow the directions on your label and from your provider.
Let it dissolve
Place the tablet on or under your tongue and let it dissolve fully. Don’t chew or swallow it whole.
Once a day, max
Don't take more than one in 24 hours.
Don't combine
Don't take it with other ED medications.
ED Combo ODT questions
Is the ED Combo ODT FDA-approved?
No. It is compounded by a state-licensed pharmacy. Sildenafil and tadalafil are FDA-approved on their own, and bremelanotide is FDA-approved as Vyleesi® for premenopausal women with low desire, but this combination is not.
Why combine ingredients?
Each ingredient works a little differently. Your provider may recommend a combination if a single medication wasn’t enough.
Can I drink alcohol with it?
A drink or two is usually fine, but heavy drinking can make erections harder and increase dizziness.
Related treatments
See if ED Combo ODT is right for you.
Answer a few questions and a licensed provider will review your options.
Important safety information
Last updated
Do not take this medication if you take nitrates or riociguat, as the combination can cause a sudden, dangerous drop in blood pressure. Sexual activity can strain your heart; stop and get medical help if you have chest pain, dizziness, or nausea during sex. Get emergency care for an erection lasting more than 4 hours, or for sudden vision or hearing loss. Tell your provider about all medications you take, including alpha-blockers and HIV medications. PT-141 (bremelanotide) can cause nausea and a temporary increase in blood pressure, and is not recommended for people with uncontrolled high blood pressure or heart disease. This combination is compounded and not FDA-approved. Vyleesi® is a registered trademark of its owner.
Compounded medication, prepared by a state-licensed pharmacy for individual patients. Compounded drugs are not FDA-approved, and the FDA does not review them for safety, effectiveness or quality. Prescribed only if your provider determines it is clinically appropriate for you.
This is not a complete list of risks. Talk with your provider and read the full prescribing information or medication guide.